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Hello,

I am Ruonan Tian

A

I specialize in multi-omics data analysis and computational framework development, with a focus on spatial transcriptomics and spatial metabolomics to decode cellular and immune heterogeneity in intestinal tissues.

Ruonan Tian

Education

  • Sep 2023 - Present

    Ph.D. student in Bioinformatics

    ZJU-UoE Institute, Zhejiang University (Supervisor: Dr. Wanlu Liu)

  • Sep 2021 - Jun 2023

    Master student in Bioinformatics

    Zhejiang University (Supervisor: Dr. Wanlu Liu)

  • Sep 2017 - Jun 2021

    Bachelor in Bioinformatics

    Huazhong Agricultural University (GPA: 3.76/4.00)

Publications

First / Co-first Authorship

Featured Publication Tian, R.*, Xue, Z.*, et al. Integrating Cross-Sample and Cross-Modal Data for Spatial Transcriptomics and Metabolomics with SpatialMETA. Nature Communications, 16, 8855 (2025). DOI
Featured Publication Zhang, J.*, Tian, R.*, et al. A two-front nutrient supply environment fuels the physiology of the small intestine through differential regulation of nutrient absorption and host defense. Cell, 187, 6251-6271.e20 (2024). DOI
Tian, R.*, Yu, Z.*, et al. Evaluation of T Cell Receptor Construction Methods from scRNA-Seq Data. Genomics, Proteomics & Bioinformatics, 22, qzae086 (2024). DOI
Tian, R.*, Xue, Z.*, et al. MSdb: an integrated expression atlas of human musculoskeletal system. iScience, 26, 106933 (2023). DOI
Ruan, D.*, Tian, R.*, et al. A Multi-Omics Atlas of Human MSCs Reveals Therapeutic Heterogeneity across Tissues and Clones. With editor in Cell.

Co-author Publications

Xue, Z.*, Wu, L.*, Tian, R., et al. Integrative mapping of human CD8+ T cells in inflammation and cancer. Nature Methods, 22, 435-445 (2024). DOI
Xue, Z.*, Wu, L.*, Gao, B.*, Tian, R., et al. Disease associated human TCR characterization by deep-learning framework TCR. Deepinsight: A pan-disease single-cell TCRαβ repertoire reference atlas. Cell Discovery, 11, 82 (2025). DOI
Chen, Y.*, Yan, Y.*, Tian, R., et al. Chemically programmed metabolism drives a superior cell fitness for cartilage regeneration. Science Advances, 10, eadp4408 (2024). DOI
Xiang, Y.*, Qian, Y.*, Li, Z.*, Wang, J.*, Tian, R., et al. Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryonic development. Science, Accepted.

Awards & Scholarships

  • National Scholarship (2025, 2023)
  • ZJU PhD "Qiushi New Star" Program (2024)
  • Outstanding Graduate Student, ZJU (2023)
  • Gold iGEM (Advisor/Leader/Member) (2018-2020)
  • First Prize, Bioinformatics Design Competition (2019, 2020)
  • Top 10 Stars of Entrepreneurship, HZAU (2020)

Skills

Programming

Python (PyTorch, Scanpy), R (Seurat), SQL, HTML/CSS/JS

Dry Lab

Spatial Multi-omics, scRNA-seq, Algorithm & Web Development

Wet Lab

Molecular cloning, ATAC-seq library, Spatial TCR library

Software & Database

MSdb

An integrated expression atlas of human musculoskeletal system

SpatialMETA

Integrating Cross-Sample and Cross-Modal Data for Spatial Transcriptomics and Metabolomics

Contact

Address: 718 East Haizhou Rd. Haining, Zhejiang 314400, P.R. China

Email: ruonan.23@intl.zju.edu.cn

GitHub: Ruonan Tian